Under-skin implant reverses type 1 diabetes without anti-rejection drugs

Researchers developed a technique to implant a device containing insulin-secreting cells in a pocket under the skin, reversing diabetes in mice without the need for anti-rejection drugs. It could one day provide an alternative to insulin injections.

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Once-a-day pill for stubborn cancer delivers a 62.5% positive response

In what has already been tagged as a “game-changer” for cancer treatment, the potent once-a-day tablet known as divarasib has continued to impress at Phase 1b trial stage, outperforming not just current therapies but its previous trial results.

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Brain cell gene changes linked to neuroinflammation seen in Alzheimer’s

Research has revealed how genetic changes in a specialized population of brain cells called microglia contribute to neuroinflammation and, in turn, to Alzheimer’s disease. The findings could lead to more effective, targeted therapeutics.

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Personalized medicine: The pros, cons and concerns

The term ‘personalized medicine’ is being used more and more frequently. But what does it mean? This explainer outlines what personalized medicine is, its advantages and some concerns that have been raised in relation to it.

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Younger people may be more vulnerable to arterial plaque risk factors

A study has found that moderate increases in blood pressure and cholesterol make 40-year-olds more vulnerable to developing arterial plaques, or atherosclerosis, than people over 48, suggesting earlier intervention is needed to slow the disease.

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MIT’s wearable ultrasound patch measures bladder fullness without gel

MIT researchers have designed a wearable ultrasound patch that can image the bladder as well as a conventional ultrasound does, without the need for cold gel or an operator. The device could also be adapted to image other internal organs.

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Existing drug boots out ‘sleeping’ bone cells to relieve lower back pain

In some heartening news for the 80% of Americans who will endure spinal sensitivity, researchers have found that an existing drug can be redeployed to target senescent osteoclasts – to not just take the pain away but help prevent it from coming back.

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Overactive inflammation in the brain linked to increased suicide risk

A first-of-its-kind study has identified overactive inflammation and loss of critical protective mechanisms in the brain as potential contributors to suicide risk and may lead to the use of anti-inflammatory medications as a way of reducing this risk.

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World-first whole-eye and partial-face transplant deemed a success

A huge multidisciplinary team at NYU Langone Health has successfully undertaken the world’s first whole-eye and partial-face transplant. The landmark surgery opens new possibilities for future advancements in vision therapies.

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Key discovery opens new avenue to lowering cholesterol levels

Researchers have identified a previously unknown step in the process by which dietary cholesterol is absorbed from the intestine into the bloodstream. The newfound pathway provides a potential new target for treating high cholesterol.

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