Recently, a pharmaceutical company which produces an ibuprofen suspension in sugar syrup was having production challenges. The company had been developing a new product with the use of traditional agitators and had been using kaolin, a type of silicate material, to keep the product in suspension and increase stability. Ideally, they wanted to remove the kaolin from the formulation and reduce the ibuprofen particles down to a much smaller size, but this was not possible with their agitator since it did not provide the shear energy needed to reduce particle size.
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